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Osteocalcin Ameliorates Motor Dysfunction in a 6-Hydroxydopamine-Induced Parkinson’s Disease Rat Model Through AKT/GSK3β Signaling

Osteoblasts derived osteocalcin (OCN) is recently reported to be involved in dopaminergic neuronal development. As dopaminergic neuronal injury in the substantia nigra (SN) is a pathological hallmark of Parkinson’s disease (PD), we investigated whether OCN could exert protective effects on 6-hydroxy...

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Detalles Bibliográficos
Autores principales: Guo, Xing-zhi, Shan, Chang, Hou, Yan-fang, Zhu, Geng, Tao, Bei, Sun, Li-hao, Zhao, Hong-yan, Ning, Guang, Li, Sheng-tian, Liu, Jian-min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170617/
https://www.ncbi.nlm.nih.gov/pubmed/30319352
http://dx.doi.org/10.3389/fnmol.2018.00343