Benzofuran–appended 4-aminoquinazoline hybrids as epidermal growth factor receptor tyrosine kinase inhibitors: synthesis, biological evaluation and molecular docking studies

A series of 2-arylbenzo[b]furan–appended 4-aminoquinazoline hybrids were prepared and evaluated for cytotoxicity in vitro against the human lung cancer (A549), colorectal adenocarcinoma (Caco-2), hepatocellular carcinoma (C3A) and cervical cancer (HeLa) cell lines. Compounds 10d and 10j exhibited si...

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Detalles Bibliográficos
Autores principales: Mphahlele, Malose J., Maluleka, Marole M., Aro, Abimbola, McGaw, Lyndy J., Choong, Yee Siew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171423/
https://www.ncbi.nlm.nih.gov/pubmed/30274538
http://dx.doi.org/10.1080/14756366.2018.1510919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171423/
https://www.ncbi.nlm.nih.gov/pubmed/30274538
http://dx.doi.org/10.1080/14756366.2018.1510919

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