Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice

Background: Photoreceptors, light-sensing neurons in retina, are central to vision. Photoreceptor cell death (PCD) is observed in most inherited and acquired retinal dystrophies. But the underlying molecular mechanism of PCD is unclear. Photoreceptors are sturdy neurons that survive high oxidative a...

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Detalles Bibliográficos
Autores principales: Bhatia, Vaibhav, Valdés-Sánchez, Lourdes, Rodriguez-Martinez, Daniel, Bhattacharya, Shom Shankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171737/
https://www.ncbi.nlm.nih.gov/pubmed/30345028
http://dx.doi.org/10.12688/f1000research.15579.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171737/
https://www.ncbi.nlm.nih.gov/pubmed/30345028
http://dx.doi.org/10.12688/f1000research.15579.1

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