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High tension in sarcomeres hinders myocardial relaxation: A computational study

Experiments have shown that the relaxation phase of cardiac sarcomeres during an isometric twitch is prolonged in muscles that reached a higher peak tension. However, the mechanism is not completely understood. We hypothesize that the binding of calcium to troponin is enhanced by the tension in the...

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Detalles Bibliográficos
Autores principales: Dupuis, Lauren J., Lumens, Joost, Arts, Theo, Delhaas, Tammo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171862/
https://www.ncbi.nlm.nih.gov/pubmed/30286135
http://dx.doi.org/10.1371/journal.pone.0204642