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High tension in sarcomeres hinders myocardial relaxation: A computational study
Experiments have shown that the relaxation phase of cardiac sarcomeres during an isometric twitch is prolonged in muscles that reached a higher peak tension. However, the mechanism is not completely understood. We hypothesize that the binding of calcium to troponin is enhanced by the tension in the...
Autores principales: | Dupuis, Lauren J., Lumens, Joost, Arts, Theo, Delhaas, Tammo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171862/ https://www.ncbi.nlm.nih.gov/pubmed/30286135 http://dx.doi.org/10.1371/journal.pone.0204642 |
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