Nanoparticle delivery of a tetravalent E protein subunit vaccine induces balanced, type-specific neutralizing antibodies to each dengue virus serotype

Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic shock syndrome. Dengue vaccine development is challenging because of the need to induce protection against four antigenically distinct DENV serotypes. Recent studies indicate that tetravalent DENV vaccines must induce...

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Detalles Bibliográficos
Autores principales: Metz, Stefan W., Thomas, Ashlie, Brackbill, Alex, Xianwen, Yi, Stone, Michele, Horvath, Katie, Miley, Michael J., Luft, Chris, DeSimone, Joseph M., Tian, Shaomin, de Silva, Aravinda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171938/
https://www.ncbi.nlm.nih.gov/pubmed/30248097
http://dx.doi.org/10.1371/journal.pntd.0006793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171938/
https://www.ncbi.nlm.nih.gov/pubmed/30248097
http://dx.doi.org/10.1371/journal.pntd.0006793

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