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CLOCK and BMAL1 stabilize and activate RHOA to promote F-actin formation in cancer cells
Circadian genes control most of the physiological functions in cancer cells, including cell proliferation, migration, and invasion. The CLOCK and BMAL1 complex plays a central role in circadian rhythms. Previous studies have shown that circadian genes may act as oncogenes or tumor-suppressor genes....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172197/ https://www.ncbi.nlm.nih.gov/pubmed/30287810 http://dx.doi.org/10.1038/s12276-018-0156-4 |