Cargando…

CLOCK and BMAL1 stabilize and activate RHOA to promote F-actin formation in cancer cells

Circadian genes control most of the physiological functions in cancer cells, including cell proliferation, migration, and invasion. The CLOCK and BMAL1 complex plays a central role in circadian rhythms. Previous studies have shown that circadian genes may act as oncogenes or tumor-suppressor genes....

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Teng-jiao, Zhang, Zhi-wei, Lu, Yi-lu, Zhang, Ying-ying, Tao, Da-chang, Liu, Yun-qiang, Ma, Yong-xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172197/ https://www.ncbi.nlm.nih.gov/pubmed/30287810 http://dx.doi.org/10.1038/s12276-018-0156-4

Ejemplares similares

RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer
por: Zheng, Xulei, et al.
Publicado: (2019)

Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK
por: Lu, Yilu, et al.
Publicado: (2017)

REGγ regulates circadian clock by modulating BMAL1 protein stability
por: Kubra, Syeda, et al.
Publicado: (2021)

Necdin regulates BMAL1 stability and circadian clock through SGT1-HSP90 chaperone machinery
por: Lu, Renbin, et al.
Publicado: (2020)

Regulation of circadian clock transcriptional output by CLOCK:BMAL1
por: Trott, Alexandra J., et al.
Publicado: (2018)

Disruption of the Clock Components CLOCK and BMAL1 Leads to Hypoinsulinemia and Diabetes
por: Marcheva, Biliana, et al.
Publicado: (2010)

Nuclear envelope protein MAN1 regulates clock through BMAL1
por: Lin, Shu-Ting, et al.
Publicado: (2014)

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock
por: Ye, Rui, et al.
Publicado: (2014)

Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK
por: Langmesser, Sonja, et al.
Publicado: (2008)

The aging clock: to ‘BMAL'icious toward learning and memory
por: Gerstner, Jason R.
Publicado: (2010)

BMAL1 dephosphorylation determines the pace of the circadian clock
por: Schibler, Ueli
Publicado: (2021)

Emerging Insight Into the Role of Circadian Clock Gene BMAL1 in Cellular Senescence
por: Zhang, Wenqian, et al.
Publicado: (2022)

Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
por: Dang, Fabin, et al.
Publicado: (2016)

Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy
por: Wu, Hao, et al.
Publicado: (2021)

BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis
por: Rudic, R. Daniel, et al.
Publicado: (2004)

Circadian clock gene Clock-Bmal1 regulates cellular senescence in Chronic obstructive pulmonary disease
por: Li, Lingling, et al.
Publicado: (2022)

CLOCK:BMAL1 is a pioneer-like transcription factor
por: Menet, Jerome S., et al.
Publicado: (2014)

Opposite Carcinogenic Effects of Circadian Clock Gene BMAL1
por: Korkmaz, Tuba, et al.
Publicado: (2018)

The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration
por: Stokes, Kyle, et al.
Publicado: (2017)

The circadian clock component BMAL1 regulates osteogenesis in osseointegration
por: Deng, Shiyong, et al.
Publicado: (2022)

PIWIL1 suppresses circadian rhythms through GSK3β‐induced phosphorylation and degradation of CLOCK and BMAL1 in cancer cells
por: Tan, Hao, et al.
Publicado: (2019)

Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity
por: Klemz, Sabrina, et al.
Publicado: (2021)

Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids
por: Umemura, Yasuhiro, et al.
Publicado: (2021)

p75NTR promotes tooth rhythmic mineralization via upregulation of BMAL1/CLOCK
por: Xie, Bo, et al.
Publicado: (2023)

Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells
por: Zhang, Weiyun, et al.
Publicado: (2022)

Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXR [Formula: see text]-Regulated and CLOCK/BMAL1-Regulated Systems
por: Nakamura, Koh-ichi, et al.
Publicado: (2008)

PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1
por: Wang, Shuai, et al.
Publicado: (2022)

Circadian Clock Component BMAL1 in the Paraventricular Nucleus Regulates Glucose Metabolism
por: Nakata, Masanori, et al.
Publicado: (2021)

E3 ubiquitin ligase HRD1 modulates the circadian clock through regulation of BMAL1 stability
por: Guo, Dongkai, et al.
Publicado: (2020)

Effects of BMAL1 Manipulation on the Brain’s Master Circadian Clock and Behavior
por: Haque, Samreen N., et al.
Publicado: (2019)

Deficiency of the Circadian Clock Gene Bmal1 Reduces Microglial Immunometabolism
por: Wang, Xiao-Lan, et al.
Publicado: (2020)

Association of BMAL1 clock gene polymorphisms with fasting glucose in children
por: Yang, Yi-De, et al.
Publicado: (2023)

VASP Activation via the Gα13/RhoA/PKA Pathway Mediates Cucurbitacin-B-Induced Actin Aggregation and Cofilin-Actin Rod Formation
por: Zhang, Yan-Ting, et al.
Publicado: (2014)

BMAL1 but not CLOCK is associated with monochromatic green light-induced circadian rhythm of melatonin in chick pinealocytes
por: Ma, Shuhui, et al.
Publicado: (2018)

BMAL1 collaborates with CLOCK to directly promote DNA double-strand break repair and tumor chemoresistance
por: Zhang, Canfeng, et al.
Publicado: (2023)

RhoA/ROCK regulation of neuritogenesis via profilin IIa–mediated control of actin stability
por: Da Silva, Jorge Santos, et al.
Publicado: (2003)

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1
por: Shen, Yang, et al.
Publicado: (2021)

BMAL1 LINKS THE CIRCADIAN CLOCK TO VIRAL AIRWAY PATHOLOGY AND ASTHMA PHENOTYPES
por: Ehlers, Anna, et al.
Publicado: (2017)

Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
por: Lavtar, Polona, et al.
Publicado: (2018)

Deficiency of the clock gene Bmal1 affects neural progenitor cell migration
por: Ali, Amira A. H., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ogdooggs6a82rvioj5hjqvo9q0