Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors

The calcium/calmodulin-dependent protein kinases (CAMKKs) are upstream activators of CAMK1 and CAMK4 signalling and have important functions in neural development, maintenance and signalling, as well as in other aspects of biology such as Ca(2+) signalling in the cardiovascular system. To support th...

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Detalles Bibliográficos
Autores principales: Santiago, André da Silva, Couñago, Rafael M., Ramos, Priscila Zonzini, Godoi, Paulo H. C., Massirer, Katlin B., Gileadi, Opher, Elkins, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172212/
https://www.ncbi.nlm.nih.gov/pubmed/30287839
http://dx.doi.org/10.1038/s41598-018-33043-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172212/
https://www.ncbi.nlm.nih.gov/pubmed/30287839
http://dx.doi.org/10.1038/s41598-018-33043-4

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