DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1

Mutations in SWI/SNF genes are amongst the most common across all human cancers, but efficient therapeutic approaches that exploit vulnerabilities caused by SWI/SNF mutations are currently lacking. Here, we show that the SWI/SNF ATPases BRM/SMARCA2 and BRG1/SMARCA4 promote the expression of p62/GTF2...

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Detalles Bibliográficos
Autores principales: Ribeiro-Silva, Cristina, Aydin, Özge Z., Mesquita-Ribeiro, Raquel, Slyskova, Jana, Helfricht, Angela, Marteijn, Jurgen A., Hoeijmakers, Jan H. J., Lans, Hannes, Vermeulen, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172278/
https://www.ncbi.nlm.nih.gov/pubmed/30287812
http://dx.doi.org/10.1038/s41467-018-06402-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172278/
https://www.ncbi.nlm.nih.gov/pubmed/30287812
http://dx.doi.org/10.1038/s41467-018-06402-y

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