Active site alanine mutations convert deubiquitinases into high‐affinity ubiquitin‐binding proteins

A common strategy for exploring the biological roles of deubiquitinating enzymes (DUBs) in different pathways is to study the effects of replacing the wild‐type DUB with a catalytically inactive mutant in cells. We report here that a commonly studied DUB mutation, in which the catalytic cysteine is...

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Detalles Bibliográficos
Autores principales: Morrow, Marie E, Morgan, Michael T, Clerici, Marcello, Growkova, Katerina, Yan, Ming, Komander, David, Sixma, Titia K, Simicek, Michal, Wolberger, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172466/
https://www.ncbi.nlm.nih.gov/pubmed/30150323
http://dx.doi.org/10.15252/embr.201745680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172466/
https://www.ncbi.nlm.nih.gov/pubmed/30150323
http://dx.doi.org/10.15252/embr.201745680

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