A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells

BACKGROUND: Drug resistance remains an unsolved clinical issue in oncology. Despite promising initial responses obtained with BRAF and MEK kinase inhibitors, resistance to treatment develops within months in virtually all melanoma patients. METHODS: Microarray analyses were performed in BRAF inhibit...

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Detalles Bibliográficos
Autores principales: Cesi, Giulia, Philippidou, Demetra, Kozar, Ines, Kim, Yeoun Jin, Bernardin, Francois, Van Niel, Guillaume, Wienecke-Baldacchino, Anke, Felten, Paul, Letellier, Elisabeth, Dengler, Sonja, Nashan, Dorothee, Haan, Claude, Kreis, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172729/
https://www.ncbi.nlm.nih.gov/pubmed/30290811
http://dx.doi.org/10.1186/s12943-018-0886-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172729/
https://www.ncbi.nlm.nih.gov/pubmed/30290811
http://dx.doi.org/10.1186/s12943-018-0886-x

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