Design and evaluation of selective butyrylcholinesterase inhibitors based on Cinchona alkaloid scaffold

This paper describes the synthesis and anticholinesterase potency of Cinchona-based alkaloids; ten quaternary derivatives of cinchonines and their corresponding pseudo-enantiomeric cinchonidines. The quaternization of quinuclidine moiety of each compound was carried out with groups diverse in their...

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Detalles Bibliográficos
Autores principales: Bosak, Anita, Ramić, Alma, Šmidlehner, Tamara, Hrenar, Tomica, Primožič, Ines, Kovarik, Zrinka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173406/
https://www.ncbi.nlm.nih.gov/pubmed/30289893
http://dx.doi.org/10.1371/journal.pone.0205193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173406/
https://www.ncbi.nlm.nih.gov/pubmed/30289893
http://dx.doi.org/10.1371/journal.pone.0205193

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