Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells

The cystine-glutamate antiporter subunit xCT suppresses iron-dependent oxidative cell death (ferroptosis) and is therefore a promising target for cancer treatment. Given that cancer cells often show resistance to xCT inhibition resulting in glutathione (GSH) deficiency, however, we here performed a...

Descripción completa

Detalles Bibliográficos
Autores principales: Okazaki, Shogo, Shintani, Subaru, Hirata, Yuki, Suina, Kentaro, Semba, Takashi, Yamasaki, Juntaro, Umene, Kiyoko, Ishikawa, Miyuki, Saya, Hideyuki, Nagano, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173468/
https://www.ncbi.nlm.nih.gov/pubmed/30333913
http://dx.doi.org/10.18632/oncotarget.26112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173468/
https://www.ncbi.nlm.nih.gov/pubmed/30333913
http://dx.doi.org/10.18632/oncotarget.26112

Ejemplares similares