Cargando…

Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells

The cystine-glutamate antiporter subunit xCT suppresses iron-dependent oxidative cell death (ferroptosis) and is therefore a promising target for cancer treatment. Given that cancer cells often show resistance to xCT inhibition resulting in glutathione (GSH) deficiency, however, we here performed a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Okazaki, Shogo, Shintani, Subaru, Hirata, Yuki, Suina, Kentaro, Semba, Takashi, Yamasaki, Juntaro, Umene, Kiyoko, Ishikawa, Miyuki, Saya, Hideyuki, Nagano, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173468/ https://www.ncbi.nlm.nih.gov/pubmed/30333913 http://dx.doi.org/10.18632/oncotarget.26112

Ejemplares similares

Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT‐targeted therapy
por: Otsuki, Yuji, et al.
Publicado: (2019)

Glutaminolysis‐related genes determine sensitivity to xCT‐targeted therapy in head and neck squamous cell carcinoma
por: Okazaki, Shogo, et al.
Publicado: (2019)

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B‐containing N‐methyl‐d‐aspartate–sensitive glutamate receptor signaling
por: Suina, Kentaro, et al.
Publicado: (2018)

MEK inhibition suppresses metastatic progression of KRAS‐mutated gastric cancer
por: Yamasaki, Juntaro, et al.
Publicado: (2022)

Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine
por: Neuberger, Arthur, et al.
Publicado: (2022)

Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer
por: Tsuchihashi, Kenji, et al.
Publicado: (2022)

Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine
por: Liu, Qiang, et al.
Publicado: (2021)

Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia
por: Sahdeo, Sunil, et al.
Publicado: (2014)

xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma
por: Sugiyama, Akiko, et al.
Publicado: (2020)

xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction
por: Cobler, Lara, et al.
Publicado: (2018)

Sulfasalazine could modulate the CD44v9‐xCT system and enhance cisplatin‐induced cytotoxic effects in metastatic bladder cancer
por: Ogihara, Koichiro, et al.
Publicado: (2019)

Structure‐Activity‐Relationship‐Aided Design and Synthesis of xCT Antiporter Inhibitors
por: Cirillo, Davide, et al.
Publicado: (2021)

The Styryl Benzoic Acid Derivative DC10 Potentiates Radiotherapy by Targeting the xCT-Glutathione Axis
por: Sarowar, Shahin, et al.
Publicado: (2022)

Chemotherapeutic xCT inhibitors sorafenib and erastin unraveled with the synaptic optogenetic function analysis tool
por: Dahlmanns, Marc, et al.
Publicado: (2017)

d-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione
por: Homma, Takujiro, et al.
Publicado: (2022)

Growth differentiation factor 15 induces cisplatin resistance through upregulation of xCT expression and glutathione synthesis in gastric cancer
por: Wang, Sheng‐Fan, et al.
Publicado: (2023)

Lung Adenocarcinoma Mouse Models Based on Orthotopic Transplantation of Syngeneic Tumor-Initiating Cells Expressing EpCAM, SCA-1, and Ly6d
por: Semba, Takashi, et al.
Publicado: (2020)

Novel Disulfiram Derivatives as ALDH1a1-Selective Inhibitors
por: Omran, Ziad
Publicado: (2022)

Aldh inhibitor restores auditory function in a mouse model of human deafness
por: Zhu, Guang-Jie, et al.
Publicado: (2020)

Mechanism of Cell Death by Combined Treatment with an xCT Inhibitor and Paclitaxel: An Alternative Therapeutic Strategy for Patients with Ovarian Clear Cell Carcinoma
por: Idei, Urara, et al.
Publicado: (2023)

Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis
por: Wang, Sheng-Fan, et al.
Publicado: (2018)

A novel method for screening the glutathione transferase inhibitors
por: Wang, Zhijun, et al.
Publicado: (2009)

Characterisation of naturally occurring isothiocyanates as glutathione reductase inhibitors
por: Li, Xia, et al.
Publicado: (2020)

Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors
por: Krasowska, Dorota, et al.
Publicado: (2019)

Aurora kinase inhibitors: Potential molecular-targeted drugs for gynecologic malignant tumors (Review)
por: Umene, Kiyoko, et al.
Publicado: (2019)

xCT increases tuberculosis susceptibility by regulating antimicrobial function and inflammation
por: Cai, Yi, et al.
Publicado: (2016)

Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo
por: Shin, Seung-Shick, et al.
Publicado: (2018)

Functional analysis of CD44 variants and xCT in canine tumours
por: Tanabe, Atsushi, et al.
Publicado: (2020)

Decreased xCT activity in patients associated with Helicobacter pylori infection
por: Wang, Ling, et al.
Publicado: (2022)

Cheminformatics Models for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase
por: Gaba, Sonam, et al.
Publicado: (2014)

Role of PEG35, Mitochondrial ALDH2, and Glutathione in Cold Fatty Liver Graft Preservation: An IGL-2 Approach
por: Bardallo, Raquel G., et al.
Publicado: (2021)

Genomic analysis of xCT-regulatory network in KSHV + primary effusion lymphomas
por: Qin, Zhiqiang, et al.
Publicado: (2016)

In vivo XCT bone characterization of lattice structured implants fabricated by additive manufacturing
por: Obaton, A-F., et al.
Publicado: (2017)

Deep Learning-based Inaccuracy Compensation in Reconstruction of High Resolution XCT Data
por: Topal, Emre, et al.
Publicado: (2020)

xCT Inhibition Increases Sensitivity to Vorinostat in a ROS-Dependent Manner
por: Miyamoto, Keiko, et al.
Publicado: (2020)

Sulfasalazine Sensitizes Polyhematoporphyrin-Mediated Photodynamic Therapy in Cholangiocarcinoma by Targeting xCT
por: Zheng, Yan-Wen, et al.
Publicado: (2021)

A Novel ALDH1A1 Inhibitor Targets Cells with Stem Cell Characteristics in Ovarian Cancer
por: Nwani, Nkechiyere G., et al.
Publicado: (2019)

Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 Inhibitors
por: Ibrahim, Ali I. M., et al.
Publicado: (2021)

A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells
por: Li, Jianfeng, et al.
Publicado: (2021)

A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer
por: Muralikrishnan, Vaishnavi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s1t66f1j0o7dci9hofmu9rc4g7