C-3- and C-4-Substituted Bicyclic Coumarin Sulfamates as Potent Steroid Sulfatase Inhibitors

[Image: see text] Synthetic routes to potent bicyclic nonsteroidal sulfamate-based active-site-directed inhibitors of the enzyme steroid sulfatase (STS), an emerging target in the treatment of postmenopausal hormone-dependent diseases, including breast cancer, are described. Sulfamate analogs 9–27 a...

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Detalles Bibliográficos
Autores principales: Ganeshapillai, Dharshini, Woo, L. W. Lawrence, Thomas, Mark P., Purohit, Atul, Potter, Barry V. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173509/
https://www.ncbi.nlm.nih.gov/pubmed/30320251
http://dx.doi.org/10.1021/acsomega.8b01383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173509/
https://www.ncbi.nlm.nih.gov/pubmed/30320251
http://dx.doi.org/10.1021/acsomega.8b01383

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