A novel rat model of comorbid PTSD and addiction reveals intersections between stress susceptibility and enhanced cocaine seeking with a role for mGlu5 receptors

PTSD is highly comorbid with cocaine use disorder (CUD), and cocaine users with PTSD + CUD are more resistant to treatment. Here we sought to develop a rat model of PTSD + CUD in order to identify the neurobiological changes underlying such comorbidity and screen potential medications for reducing c...

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Detalles Bibliográficos
Autores principales: Schwendt, Marek, Shallcross, John, Hadad, Natalie A., Namba, Mark D., Hiller, Helmut, Wu, Lizhen, Krause, Eric G., Knackstedt, Lori A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173705/
https://www.ncbi.nlm.nih.gov/pubmed/30291225
http://dx.doi.org/10.1038/s41398-018-0265-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173705/
https://www.ncbi.nlm.nih.gov/pubmed/30291225
http://dx.doi.org/10.1038/s41398-018-0265-9

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