Splenectomy modulates early immuno-inflammatory responses to trauma-hemorrhage and protects mice against secondary sepsis

In polytrauma patients, the impact of splenectomy is equivocal, ranging from negative to protective. We investigated the impact of splenectomy on immune responses in the 1(st)-hit polytrauma alone and on survival in the post-traumatic sepsis (2(nd) hit). Female BALB/c mice underwent polytrauma (1(st...

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Detalles Bibliográficos
Autores principales: Drechsler, S., Zipperle, J., Rademann, P., Jafarmadar, M., Klotz, A., Bahrami, S., Osuchowski, M. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173732/
https://www.ncbi.nlm.nih.gov/pubmed/30291296
http://dx.doi.org/10.1038/s41598-018-33232-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173732/
https://www.ncbi.nlm.nih.gov/pubmed/30291296
http://dx.doi.org/10.1038/s41598-018-33232-1

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