POxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy

POxylated polyurea dendrimer (PURE(G4)OOx(48))‐based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO(2)‐assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were pr...

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Detalles Bibliográficos
Autores principales: Restani, Rita B., Pires, Rita F., Tolmatcheva, Anna, Cabral, Rita, Baptista, Pedro V., Fernandes, Alexandra R., Casimiro, Teresa, Bonifácio, Vasco D. B., Aguiar‐Ricardo, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174550/
https://www.ncbi.nlm.nih.gov/pubmed/30338202
http://dx.doi.org/10.1002/open.201800093
Descripción
Sumario:POxylated polyurea dendrimer (PURE(G4)OOx(48))‐based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO(2)‐assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PURE(G4)OOx(48) nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX‐DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.

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