POxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy

POxylated polyurea dendrimer (PURE(G4)OOx(48))‐based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO(2)‐assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were pr...

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Autores principales: Restani, Rita B., Pires, Rita F., Tolmatcheva, Anna, Cabral, Rita, Baptista, Pedro V., Fernandes, Alexandra R., Casimiro, Teresa, Bonifácio, Vasco D. B., Aguiar‐Ricardo, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174550/
https://www.ncbi.nlm.nih.gov/pubmed/30338202
http://dx.doi.org/10.1002/open.201800093
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author Restani, Rita B.
Pires, Rita F.
Tolmatcheva, Anna
Cabral, Rita
Baptista, Pedro V.
Fernandes, Alexandra R.
Casimiro, Teresa
Bonifácio, Vasco D. B.
Aguiar‐Ricardo, Ana
author_facet Restani, Rita B.
Pires, Rita F.
Tolmatcheva, Anna
Cabral, Rita
Baptista, Pedro V.
Fernandes, Alexandra R.
Casimiro, Teresa
Bonifácio, Vasco D. B.
Aguiar‐Ricardo, Ana
author_sort Restani, Rita B.
collection PubMed
description POxylated polyurea dendrimer (PURE(G4)OOx(48))‐based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO(2)‐assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PURE(G4)OOx(48) nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX‐DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells.
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spelling pubmed-61745502018-10-18 POxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy Restani, Rita B. Pires, Rita F. Tolmatcheva, Anna Cabral, Rita Baptista, Pedro V. Fernandes, Alexandra R. Casimiro, Teresa Bonifácio, Vasco D. B. Aguiar‐Ricardo, Ana ChemistryOpen Full Papers POxylated polyurea dendrimer (PURE(G4)OOx(48))‐based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO(2)‐assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PURE(G4)OOx(48) nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX‐DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells. John Wiley and Sons Inc. 2018-07-25 /pmc/articles/PMC6174550/ /pubmed/30338202 http://dx.doi.org/10.1002/open.201800093 Text en © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Full Papers
Restani, Rita B.
Pires, Rita F.
Tolmatcheva, Anna
Cabral, Rita
Baptista, Pedro V.
Fernandes, Alexandra R.
Casimiro, Teresa
Bonifácio, Vasco D. B.
Aguiar‐Ricardo, Ana
POxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy
title POxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy
title_full POxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy
title_fullStr POxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy
title_full_unstemmed POxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy
title_short POxylated Dendrimer‐Based Nano‐in‐Micro Dry Powder Formulations for Inhalation Chemotherapy
title_sort poxylated dendrimer‐based nano‐in‐micro dry powder formulations for inhalation chemotherapy
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174550/
https://www.ncbi.nlm.nih.gov/pubmed/30338202
http://dx.doi.org/10.1002/open.201800093
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