Gaining Mechanistic Insight Into Coproporphyrin I as Endogenous Biomarker for OATP1B‐Mediated Drug–Drug Interactions Using Population Pharmacokinetic Modeling and Simulation

This study evaluated coproporphyrin I (CPI) as a selective endogenous biomarker of OATP1B‐mediated drug–drug interactions (DDIs) relative to clinical probe rosuvastatin using nonlinear mixed‐effect modeling. Plasma and urine CPI data in the presence/absence of rifampicin were modeled to describe CPI...

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Detalles Bibliográficos
Autores principales: Barnett, Shelby, Ogungbenro, Kayode, Ménochet, Karelle, Shen, Hong, Lai, Yurong, Humphreys, W. Griffith, Galetin, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175062/
https://www.ncbi.nlm.nih.gov/pubmed/29243231
http://dx.doi.org/10.1002/cpt.983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175062/
https://www.ncbi.nlm.nih.gov/pubmed/29243231
http://dx.doi.org/10.1002/cpt.983

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