Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles

Mutations in the glucosylceramidase beta (GBA) gene are strongly associated with neurodegenerative diseases marked by protein aggregation. GBA encodes the lysosomal enzyme glucocerebrosidase, which breaks down glucosylceramide. A common explanation for the link between GBA mutations and protein aggr...

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Detalles Bibliográficos
Autores principales: Thomas, Ruth E., Vincow, Evelyn S., Merrihew, Gennifer E., MacCoss, Michael J., Davis, Marie Y., Pallanck, Leo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175534/
https://www.ncbi.nlm.nih.gov/pubmed/30256786
http://dx.doi.org/10.1371/journal.pgen.1007694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175534/
https://www.ncbi.nlm.nih.gov/pubmed/30256786
http://dx.doi.org/10.1371/journal.pgen.1007694

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