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Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells

BMP4/7-dependent expression of inhibitor of differentiation/DNA binding (Id) proteins 1 and 3 has been implicated in tumor progression and poor prognosis of malignant melanoma patients. Hyaluronic acid (HA), a pericellular matrix component, supports BMP7 signalling in murine chondrocytes through its...

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Detalles Bibliográficos
Autores principales: Wu, Ruo-Lin, Sedlmeier, Georg, Kyjacova, Lenka, Schmaus, Anja, Philipp, Julia, Thiele, Wilko, Garvalov, Boyan K., Sleeman, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175841/
https://www.ncbi.nlm.nih.gov/pubmed/30297743
http://dx.doi.org/10.1038/s41598-018-33337-7