Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis

Multiple Sclerosis (MS) is characterized by focal CNS inflammation leading to the death of oligodendrocytes (OLs) with subsequent demyelination, neuronal degeneration, and severe functional deficits. Inhibitory chondroitin sulfate proteoglycans (CSPGs) are increased in the extracellular matrix in th...

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Detalles Bibliográficos
Autores principales: Luo, Fucheng, Tran, Amanda Phuong, Xin, Li, Sanapala, Chandrika, Lang, Bradley T., Silver, Jerry, Yang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175851/
https://www.ncbi.nlm.nih.gov/pubmed/30297691
http://dx.doi.org/10.1038/s41467-018-06505-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175851/
https://www.ncbi.nlm.nih.gov/pubmed/30297691
http://dx.doi.org/10.1038/s41467-018-06505-6

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