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Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells

Infection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection wi...

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Detalles Bibliográficos
Autores principales: Straub, Tobias, Freudenberg, Marina A., Schleicher, Ulrike, Bogdan, Christian, Gasteiger, Georg, Pircher, Hanspeter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175863/
https://www.ncbi.nlm.nih.gov/pubmed/30297690
http://dx.doi.org/10.1038/s41467-018-06609-z