Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation

The developmental pathways of broadly neutralizing antibodies (bNAbs) against HIV are of great importance for the design of immunogens that can elicit protective responses. Here we show the maturation features of the HIV-neutralizing anti-V1V2 VRC26 lineage by simultaneously sequencing the exon toge...

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Detalles Bibliográficos
Autores principales: Johnson, Erik L., Doria-Rose, Nicole A., Gorman, Jason, Bhiman, Jinal N., Schramm, Chaim A., Vu, Ashley Q., Law, William H., Zhang, Baoshan, Bekker, Valerie, Abdool Karim, Salim S., Ippolito, Gregory C., Morris, Lynn, Moore, Penny L., Kwong, Peter D., Mascola, John R., Georgiou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175870/
https://www.ncbi.nlm.nih.gov/pubmed/30297708
http://dx.doi.org/10.1038/s41467-018-06424-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175870/
https://www.ncbi.nlm.nih.gov/pubmed/30297708
http://dx.doi.org/10.1038/s41467-018-06424-6

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