Mannich base limits Candida albicans virulence by inactivating Ras-cAMP-PKA pathway

Mannich bases and its derivatives are regarded as supreme pharmacophores in therapeutics. The study investigates the antimycotic potential of Mannich bases, 1-((1H-benzimidazol-1-yl) methyl) urea (C1) and 1-((3-hydroxynapthalen-2-yl) methyl) thiourea (C2), against Candida albicans. Biofilm and hypha...

Descripción completa

Detalles Bibliográficos
Autores principales: Rajasekharan, Satish Kumar, Kamalanathan, Chakkaravarthi, Ravichandran, Vinothkannan, Ray, Arvind Kumar, Satish, Ann Susan, Mohanvel, Sucharitha Kannappan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175908/
https://www.ncbi.nlm.nih.gov/pubmed/30297833
http://dx.doi.org/10.1038/s41598-018-32935-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175908/
https://www.ncbi.nlm.nih.gov/pubmed/30297833
http://dx.doi.org/10.1038/s41598-018-32935-9

Ejemplares similares