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Mannich base limits Candida albicans virulence by inactivating Ras-cAMP-PKA pathway

Mannich bases and its derivatives are regarded as supreme pharmacophores in therapeutics. The study investigates the antimycotic potential of Mannich bases, 1-((1H-benzimidazol-1-yl) methyl) urea (C1) and 1-((3-hydroxynapthalen-2-yl) methyl) thiourea (C2), against Candida albicans. Biofilm and hypha...

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Detalles Bibliográficos
Autores principales:	Rajasekharan, Satish Kumar, Kamalanathan, Chakkaravarthi, Ravichandran, Vinothkannan, Ray, Arvind Kumar, Satish, Ann Susan, Mohanvel, Sucharitha Kannappan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175908/ https://www.ncbi.nlm.nih.gov/pubmed/30297833 http://dx.doi.org/10.1038/s41598-018-32935-9

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