Vav1 mutations identified in human cancers give rise to different oncogenic phenotypes

Vav1 is physiologically active as a GDP/GTP nucleotide exchange factor (GEF) in the hematopoietic system. Overexpression of Vav1 in multiple tumor types is known to enhance oncogenicity, yet whether or not Vav1 is a bona fide oncogene is still a matter of debate. Although mutations in Vav1 were rece...

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Detalles Bibliográficos
Autores principales: Shalom, Batel, Farago, Marganit, Pikarsky, Eli, Katzav, Shulamit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175932/
https://www.ncbi.nlm.nih.gov/pubmed/30297765
http://dx.doi.org/10.1038/s41389-018-0091-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175932/
https://www.ncbi.nlm.nih.gov/pubmed/30297765
http://dx.doi.org/10.1038/s41389-018-0091-1

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