Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice

ARHGEF6 belongs to the family of guanine nucleotide exchange factors (GEFs) for Rho GTPases, and it specifically activates Rho GTPases CDC42 and RAC1. Arhgef6 is the X-linked intellectual disability gene also known as XLID46, and clinical features of patients carrying Arhgef6 mutations include intel...

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Detalles Bibliográficos
Autores principales: Zhu, Chengwen, Cheng, Cheng, Wang, Yanfei, Muhammad, Waqas, Liu, Shuang, Zhu, Weijie, Shao, Buwei, Zhang, Zhong, Yan, Xiaoqian, He, Qingqing, Xu, Zhengrong, Yu, Chenjie, Qian, Xiaoyun, Lu, Ling, Zhang, Shasha, Zhang, Yuan, Xiong, Wei, Gao, Xia, Xu, Zhigang, Chai, Renjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176010/
https://www.ncbi.nlm.nih.gov/pubmed/30333726
http://dx.doi.org/10.3389/fnmol.2018.00362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176010/
https://www.ncbi.nlm.nih.gov/pubmed/30333726
http://dx.doi.org/10.3389/fnmol.2018.00362

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