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Tracing Antibody Repertoire Evolution by Systems Phylogeny

Antibody evolution studies have been traditionally limited to either tracing a single clonal lineage (B cells derived from a single V-(D)-J recombination) over time or examining bulk functionality changes (e.g., tracing serum polyclonal antibody proteins). Studying a single B cell disregards the maj...

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Detalles Bibliográficos
Autores principales: Yermanos, Alexander Dimitri, Dounas, Andreas Kevin, Stadler, Tanja, Oxenius, Annette, Reddy, Sai T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176079/
https://www.ncbi.nlm.nih.gov/pubmed/30333820
http://dx.doi.org/10.3389/fimmu.2018.02149