Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells

S-phase kinase-associated protein2 (Skp2), a proto-oncoprotein, plays an important role in development and progression of human malignancies. Skp2 is frequently overexpressed in many human malignancies. It targets cell cycle progression through ubiquitin mediated degradation of G1-checkpoint CDK inh...

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Detalles Bibliográficos
Autores principales: Khan, Abdul Q., Siveen, Kodappully S., Prabhu, Kirti S., Kuttikrishnan, Shilpa, Akhtar, Sabah, Shaar, Abdullah, Raza, Afsheen, Mraiche, Fatima, Dermime, Said, Uddin, Shahab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176276/
https://www.ncbi.nlm.nih.gov/pubmed/30333956
http://dx.doi.org/10.3389/fonc.2018.00399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176276/
https://www.ncbi.nlm.nih.gov/pubmed/30333956
http://dx.doi.org/10.3389/fonc.2018.00399

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