A 20(S)-protopanaxadiol derivative PPD12 reverses ABCB1-mediated multidrug resistance with oral bioavailability and low toxicity

The ATP-binding cassette subfamily B member 1 (ABCB1) is a transporter that mediates multidrug resistance (MDR) against chemotherapy, which leads to decreased patient survival. To inhibit ABCB1 activity in MDR cancer cells, the authors previously designed and synthesized a derivative from 20(S)-prot...

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Detalles Bibliográficos
Autores principales: Wei, Shunfeng, Chen, Wantao, Hu, Lihong, Pan, Jinsong, Wang, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176371/
https://www.ncbi.nlm.nih.gov/pubmed/30344740
http://dx.doi.org/10.3892/ol.2018.9338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176371/
https://www.ncbi.nlm.nih.gov/pubmed/30344740
http://dx.doi.org/10.3892/ol.2018.9338

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