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Hepatocyte growth factor-induced mesenchymal-epithelial transition factor activation leads to insulin-like growth factor 1 receptor inhibitor unresponsiveness in gastric cancer cells

Insulin-like growth factor 1 receptor (IGF-1R) inhibitors have been developed as potential therapeutics for cancer treatment; however, the phase III trials have not produced promising overall survival rates. Therefore, understanding the mechanism underlying intrinsic resistance to IGF-1R-targeted ag...

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Detalles Bibliográficos
Autores principales: Liu, Rujiao, Tang, Wenbo, Han, Xiaotian, Geng, Ruixuan, Wang, Chenchen, Zhang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176415/
https://www.ncbi.nlm.nih.gov/pubmed/30333869
http://dx.doi.org/10.3892/ol.2018.9414