Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical

All cells obtain 2′-deoxyribonucleotides for DNA synthesis through the activity of a ribonucleotide reductase (RNR). The class I RNRs found in humans and pathogenic bacteria differ in (i) use of Fe(II), Mn(II), or both for activation of the dinuclear-metallocofactor subunit, β; (ii) reaction of the...

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Detalles Bibliográficos
Autores principales: Blaesi, Elizabeth J., Palowitch, Gavin M., Hu, Kai, Kim, Amelia J., Rose, Hannah R., Alapati, Rahul, Lougee, Marshall G., Kim, Hee Jong, Taguchi, Alexander T., Tan, Kong Ooi, Laremore, Tatiana N., Griffin, Robert G., Krebs, Carsten, Matthews, Megan L., Silakov, Alexey, Bollinger, J. Martin, Allen, Benjamin D., Boal, Amie K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176560/
https://www.ncbi.nlm.nih.gov/pubmed/30224458
http://dx.doi.org/10.1073/pnas.1811993115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176560/
https://www.ncbi.nlm.nih.gov/pubmed/30224458
http://dx.doi.org/10.1073/pnas.1811993115

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