Targeting intramolecular proteinase NS2B/3 cleavages for trans-dominant inhibition of dengue virus

Many positive-strand RNA viruses translate their genomes as single polyproteins that are processed by host and viral proteinases to generate all viral protein products. Among these is dengue virus, which encodes the serine proteinase NS2B/3 responsible for seven different cleavages in the polyprotei...

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Detalles Bibliográficos
Autores principales: Constant, David A., Mateo, Roberto, Nagamine, Claude M., Kirkegaard, Karla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176606/
https://www.ncbi.nlm.nih.gov/pubmed/30228122
http://dx.doi.org/10.1073/pnas.1805195115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176606/
https://www.ncbi.nlm.nih.gov/pubmed/30228122
http://dx.doi.org/10.1073/pnas.1805195115

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