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Targeting intramolecular proteinase NS2B/3 cleavages for trans-dominant inhibition of dengue virus
Many positive-strand RNA viruses translate their genomes as single polyproteins that are processed by host and viral proteinases to generate all viral protein products. Among these is dengue virus, which encodes the serine proteinase NS2B/3 responsible for seven different cleavages in the polyprotei...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176606/ https://www.ncbi.nlm.nih.gov/pubmed/30228122 http://dx.doi.org/10.1073/pnas.1805195115 |