Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer

The TBX1 gene is haploinsufficient in 22q11.2 deletion syndrome (22q11.2DS), and genetic evidence from human patients and mouse models points to a major role of this gene in the pathogenesis of this syndrome. Tbx1 can activate and repress transcription, and previous work has shown that one of its fu...

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Detalles Bibliográficos
Autores principales: Pane, Luna Simona, Fulcoli, Filomena Gabriella, Cirino, Andrea, Altomonte, Alessandra, Ferrentino, Rosa, Bilio, Marchesa, Baldini, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176997/
https://www.ncbi.nlm.nih.gov/pubmed/30166330
http://dx.doi.org/10.1242/dmm.029967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176997/
https://www.ncbi.nlm.nih.gov/pubmed/30166330
http://dx.doi.org/10.1242/dmm.029967

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