Cargando…

A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis

Hepatic steatosis, a reversible state of metabolic dysregulation, can promote the onset of nonalcoholic steatohepatitis (NASH), and its transition is thought to be critical in disease evolution. The association between endoplasmic reticulum (ER) stress response and hepatocyte metabolism disorders pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parafati, Maddalena, Kirby, R. Jason, Khorasanizadeh, Sepideh, Rastinejad, Fraydoon, Malany, Siobhan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176998/ https://www.ncbi.nlm.nih.gov/pubmed/30254132 http://dx.doi.org/10.1242/dmm.033530

Ejemplares similares

Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation
por: Parafati, Maddalena, et al.
Publicado: (2020)

Corecognition of DNA and a methylated histone tail by MSL3 chromodomain
por: Kim, Daesung, et al.
Publicado: (2010)

The protein architecture and allosteric landscape of HNF4α
por: Rastinejad, Fraydoon
Publicado: (2023)

Bidirectional Modulation of HIF-2 Activity through Chemical Ligands
por: Wu, Dalei, et al.
Publicado: (2019)

Microphysiological system for studying contractile differences in young, active, and old, sedentary adult derived skeletal muscle cells
por: Giza, Shelby, et al.
Publicado: (2022)

Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases
por: Guo, Beichu, et al.
Publicado: (2014)

Hepatocyte-specific PKCβ deficiency protects against high-fat diet-induced nonalcoholic hepatic steatosis
por: Shu, Yaoling, et al.
Publicado: (2020)

Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions
por: Komeili Movahhed, Tahereh, et al.
Publicado: (2019)

Induction of Liver Steatosis in BAP31-Deficient Mice Burdened with Tunicamycin-Induced Endoplasmic Reticulum Stress
por: Wu, Zhenhua, et al.
Publicado: (2018)

Endoplasmic reticulum stress induces hepatic plasminogen activator inhibitor 1 in murine nonalcoholic steatohepatitis
por: Olivares, Shantel, et al.
Publicado: (2020)

Modeling human hepatic steatosis in pluripotent stem cell-derived hepatocytes
por: Sinton, Matthew C., et al.
Publicado: (2021)

Protective effect of mild endoplasmic reticulum stress on radiation-induced bystander effects in hepatocyte cells
por: Xie, Yuexia, et al.
Publicado: (2016)

Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats
por: Su, Wei, et al.
Publicado: (2020)

Homocysteine Inhibits Hepatocyte Proliferation via Endoplasmic Reticulum Stress
por: Yu, Xue, et al.
Publicado: (2013)

Livogrit Prevents Methionine-Cystine Deficiency Induced Nonalcoholic Steatohepatitis by Modulation of Steatosis and Oxidative Stress in Human Hepatocyte-Derived Spheroid and in Primary Rat Hepatocytes
por: Balkrishna, Acharya, et al.
Publicado: (2022)

High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis
por: Pradip, Arvind, et al.
Publicado: (2016)

Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca(2+)-handling proteins
por: Papp, S., et al.
Publicado: (2003)

Effects of Naltrexone on Expression of Lipid Metabolism-Related Proteins in Liver Steatosis Induced by Endoplasmic Reticulum Stress in Mice
por: Yang, Ping, et al.
Publicado: (2022)

Endoplasmic reticulum membrane potassium channel dysfunction in high fat diet induced stress in rat hepatocytes
por: Khodaee, Naser, et al.
Publicado: (2014)

S‐allyl‐L‐cysteine protects hepatocytes from indomethacin‐induced apoptosis by attenuating endoplasmic reticulum stress
por: Chen, Peng, et al.
Publicado: (2020)

The Effect and Mechanism of Tamoxifen-Induced Hepatocyte Steatosis in Vitro
por: Zhao, Fei, et al.
Publicado: (2014)

An in vitro model of hepatic steatosis using lipid loaded induced pluripotent stem cell derived hepatocyte like cells
por: Deepak, Hiraganahalli Bhaskar, et al.
Publicado: (2020)

Gating Behavior of Endoplasmic Reticulum Potassium Channels of Rat Hepatocytes in Diabetes
por: Ghasemi, Maedeh, et al.
Publicado: (2014)

Overexpression of apolipoprotein A-I alleviates endoplasmic reticulum stress in hepatocytes
por: Guo, Qing, et al.
Publicado: (2017)

Dexmedetomidine alleviates insulin resistance in hepatocytes by reducing endoplasmic reticulum stress
por: Liu, Fanfan, et al.
Publicado: (2019)

SUN-LB137 Endocannabinoids Induce Endoplasmic Reticulum Stress in Hepatocytes and Human Coronary Artery Endothelial Cells
por: Richter, Angela, et al.
Publicado: (2020)

Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice
por: Takahara, Ikuko, et al.
Publicado: (2017)

Vitamin D Binding Protein: A Historic Overview
por: Bouillon, Roger, et al.
Publicado: (2020)

Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis
por: Daugherty, Alan, et al.
Publicado: (2019)

Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease
por: Wang, Jin, et al.
Publicado: (2020)

DIFFERENTIATION OF ENDOPLASMIC RETICULUM IN HEPATOCYTES : II. Glucose-6-Phosphatase in Rough Microsomes
por: Leskes, A., et al.
Publicado: (1971)

DIFFERENTIATION OF ENDOPLASMIC RETICULUM IN HEPATOCYTES : I. Glucose-6-Phosphatase Distribution In Situ
por: Leskes, A., et al.
Publicado: (1971)

Zinc Attenuates the Cytotoxicity of Some Stimuli by Reducing Endoplasmic Reticulum Stress in Hepatocytes
por: Kusanaga, Masashi, et al.
Publicado: (2019)

Retraction Note: Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives
por: Rajamani, Uthra, et al.
Publicado: (2019)

RETRACTED ARTICLE:Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives
por: Rajamani, Uthra, et al.
Publicado: (2017)

Correction: Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice
por: Takahara, Ikuko, et al.
Publicado: (2020)

Mechanisms of Hypercapnia-Induced Endoplasmic Reticulum Dysfunction
por: Kryvenko, Vitalii, et al.
Publicado: (2021)

Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress
por: Zhang, Zhiguo, et al.
Publicado: (2016)

SUN-106 Loss of Coordination in the Expression of Hepatic Lipase and Endoplasmic Reticulum Stress Genes in Steatosis
por: Havighorst, Amanda, et al.
Publicado: (2019)

Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis
por: Kim, Byeong-Moo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_que3h9i2c1lacmo5p26lbgg6jg