Cargando…
A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis
Hepatic steatosis, a reversible state of metabolic dysregulation, can promote the onset of nonalcoholic steatohepatitis (NASH), and its transition is thought to be critical in disease evolution. The association between endoplasmic reticulum (ER) stress response and hepatocyte metabolism disorders pr...
Autores principales: | Parafati, Maddalena, Kirby, R. Jason, Khorasanizadeh, Sepideh, Rastinejad, Fraydoon, Malany, Siobhan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176998/ https://www.ncbi.nlm.nih.gov/pubmed/30254132 http://dx.doi.org/10.1242/dmm.033530 |
Ejemplares similares
-
Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation
por: Parafati, Maddalena, et al.
Publicado: (2020) -
Corecognition of DNA and a methylated histone tail by MSL3 chromodomain
por: Kim, Daesung, et al.
Publicado: (2010) -
The protein architecture and allosteric landscape of HNF4α
por: Rastinejad, Fraydoon
Publicado: (2023) -
Bidirectional Modulation of HIF-2 Activity through Chemical Ligands
por: Wu, Dalei, et al.
Publicado: (2019) -
Microphysiological system for studying contractile differences in young, active, and old, sedentary adult derived skeletal muscle cells
por: Giza, Shelby, et al.
Publicado: (2022)