Immunomodulation with minocycline rescues retinal degeneration in juvenile neuronal ceroid lipofuscinosis mice highly susceptible to light damage

Juvenile neuronal ceroid lipofuscinosis (jNCL) is a rare but fatal inherited lysosomal storage disorder mainly affecting children. The disease is caused by mutations in the CLN3 gene that lead to the accumulation of storage material in many tissues, prominent immune responses and neuronal degenerati...

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Detalles Bibliográficos
Autores principales: Dannhausen, Katharina, Möhle, Christoph, Langmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176999/
https://www.ncbi.nlm.nih.gov/pubmed/30042155
http://dx.doi.org/10.1242/dmm.033597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176999/
https://www.ncbi.nlm.nih.gov/pubmed/30042155
http://dx.doi.org/10.1242/dmm.033597

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