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Aberrant cerebellar Purkinje cell activity as the cause of motor attacks in a mouse model of episodic ataxia type 2

Many cerebellar-induced neurological disorders, such as ataxias and cerebellar-induced dystonias, are associated with abnormal Purkinje cell activity. In tottering mice, a well-established mouse model of episodic ataxia type 2 (EA2), cerebellar Purkinje cells are required for the initiation of motor...

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Detalles Bibliográficos
Autores principales: Tara, Esra, Vitenzon, Ariel, Hess, Ellen, Khodakhah, Kamran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177005/
https://www.ncbi.nlm.nih.gov/pubmed/30279196
http://dx.doi.org/10.1242/dmm.034181