Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance

We have previously reported that homologous recombination (HR) is dysregulated in multiple myeloma (MM) and contributes to genomic instability and development of drug resistance. We now demonstrate that base excision repair (BER) associated apurinic/apyrimidinic (AP) nucleases (APEX1 and APEX2) cont...

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Detalles Bibliográficos
Autores principales: Kumar, Subodh, Talluri, Srikanth, Pal, Jagannath, Yuan, Xiaoli, Lu, Renquan, Nanjappa, Puru, Samur, Mehmet K., Munshi, Nikhil C., Shammas, Masood A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177467/
https://www.ncbi.nlm.nih.gov/pubmed/30301882
http://dx.doi.org/10.1038/s41408-018-0129-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177467/
https://www.ncbi.nlm.nih.gov/pubmed/30301882
http://dx.doi.org/10.1038/s41408-018-0129-9

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