Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

New drugs are needed to control the current tuberculosis (TB) pandemic caused by infection with Mycobacterium tuberculosis. We report here on our work with AX-35, an arylvinylpiperazine amide, and four related analogs, which are potent antitubercular agents in vitro. All five compounds showed good a...

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Detalles Bibliográficos
Autores principales: Foo, Caroline S., Lupien, Andréanne, Kienle, Maryline, Vocat, Anthony, Benjak, Andrej, Sommer, Raphael, Lamprecht, Dirk A., Steyn, Adrie J. C., Pethe, Kevin, Piton, Jérémie, Altmann, Karl-Heinz, Cole, Stewart T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178619/
https://www.ncbi.nlm.nih.gov/pubmed/30301850
http://dx.doi.org/10.1128/mBio.01276-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178619/
https://www.ncbi.nlm.nih.gov/pubmed/30301850
http://dx.doi.org/10.1128/mBio.01276-18

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