Cargando…

Protein S K196E mutation reduces its cofactor activity for APC but not for TFPI

BACKGROUND: Protein S (PS) is an anticoagulant molecule that functions as a cofactor for activated protein C (APC) in the inactivation of activated coagulation factors Va (FVa) and VIIIa. It also serves as a cofactor for tissue factor pathway inhibitor (TFPI) in the efficient inhibition of factor Xa...

Descripción completa

Detalles Bibliográficos
Autores principales: Maruyama, Keiko, Akiyama, Masashi, Miyata, Toshiyuki, Kokame, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178719/
https://www.ncbi.nlm.nih.gov/pubmed/30349894
http://dx.doi.org/10.1002/rth2.12152