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Protein S K196E mutation reduces its cofactor activity for APC but not for TFPI

BACKGROUND: Protein S (PS) is an anticoagulant molecule that functions as a cofactor for activated protein C (APC) in the inactivation of activated coagulation factors Va (FVa) and VIIIa. It also serves as a cofactor for tissue factor pathway inhibitor (TFPI) in the efficient inhibition of factor Xa...

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Detalles Bibliográficos
Autores principales:	Maruyama, Keiko, Akiyama, Masashi, Miyata, Toshiyuki, Kokame, Koichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles: Thrombosis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178719/ https://www.ncbi.nlm.nih.gov/pubmed/30349894 http://dx.doi.org/10.1002/rth2.12152

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