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Indoleamine 2,3‐dioxygenase 1 in coronary atherosclerotic plaque enhances tissue factor expression in activated macrophages

BACKGROUND: Recent clinical studies have found that changes in the kynurenine (Kyn) pathway of tryptophan (Trp) metabolism are associated with cardiovascular events. However, the roles of the Kyn pathway on vascular wall thrombogenicity remain unknown. Indoleamine 2,3‐dioxygenase 1 (IDO1) is a rate‐...

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Detalles Bibliográficos
Autores principales: Watanabe, Yuki, Koyama, Shohei, Yamashita, Atsushi, Matsuura, Yunosuke, Nishihira, Kensaku, Kitamura, Kazuo, Asada, Yujiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178752/
https://www.ncbi.nlm.nih.gov/pubmed/30349892
http://dx.doi.org/10.1002/rth2.12128