Design, synthesis and biological evaluation of tricyclic pyrazolo[1,5-c][1,3]benzoxazin-5(5H)-one scaffolds as selective BuChE inhibitors

Based on the structural analysis of tricyclic scaffolds as butyrylcholinesterase (BuChE) inhibitors, a series of pyrazolo[1,5-c][1,3]benzoxazin-5(5H)-one derivatives were designed, synthesized and evaluated for their acetylcholinesterase (AChE) and BuChE inhibitory activity. Compounds with 5-carbony...

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Detalles Bibliográficos
Autores principales: Qiu, Guo-Liang, He, Shao-Sheng, Chen, Shi-Chao, Li, Bo, Wu, Hui-Hui, Zhang, Jing, Tang, Wen-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179045/
https://www.ncbi.nlm.nih.gov/pubmed/30284486
http://dx.doi.org/10.1080/14756366.2018.1488696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179045/
https://www.ncbi.nlm.nih.gov/pubmed/30284486
http://dx.doi.org/10.1080/14756366.2018.1488696

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