Impaired myogenic development, differentiation and function in hESC-derived SMA myoblasts and myotubes

Spinal muscular atrophy (SMA) is a severe genetic disorder that manifests in progressive neuromuscular degeneration. SMA originates from loss-of-function mutations of the SMN1 (Survival of Motor Neuron 1) gene. Recent evidence has implicated peripheral deficits, especially in skeletal muscle, as key...

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Detalles Bibliográficos
Autores principales: Hellbach, Nicole, Peterson, Suzanne, Haehnke, Daniel, Shankar, Aditi, LaBarge, Samuel, Pivaroff, Cullen, Saenger, Stefanie, Thomas, Carolin, McCarthy, Kathleen, Ebeling, Martin, Hayhurst Bennett, Monica, Schmidt, Uli, Metzger, Friedrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179271/
https://www.ncbi.nlm.nih.gov/pubmed/30304024
http://dx.doi.org/10.1371/journal.pone.0205589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179271/
https://www.ncbi.nlm.nih.gov/pubmed/30304024
http://dx.doi.org/10.1371/journal.pone.0205589

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