Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons

Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease involving loss of motor neurons (MNs) and muscle atrophy, still has no effective treatment, despite much research effort. To provide a platform for testing drug candidates and investigating the pathogenesis of ALS, we devel...

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Detalles Bibliográficos
Autores principales: Osaki, Tatsuya, Uzel, Sebastien G. M., Kamm, Roger D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179377/
https://www.ncbi.nlm.nih.gov/pubmed/30324134
http://dx.doi.org/10.1126/sciadv.aat5847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179377/
https://www.ncbi.nlm.nih.gov/pubmed/30324134
http://dx.doi.org/10.1126/sciadv.aat5847

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