Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides To Form Nitriles

[Image: see text] A palladium(II) catalyst, in the presence of Selectfluor, enables the efficient and chemoselective transformation of primary amides into nitriles. The amides can be attached to aromatic rings, heteroaromatic rings, or aliphatic side chains, and the reactions tolerate steric bulk an...

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Detalles Bibliográficos
Autores principales: Al-Huniti, Mohammed H., Rivera-Chávez, José, Colón, Katsuya L., Stanley, Jarrod L., Burdette, Joanna E., Pearce, Cedric J., Oberlies, Nicholas H., Croatt, Mitchell P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179452/
https://www.ncbi.nlm.nih.gov/pubmed/30221526
http://dx.doi.org/10.1021/acs.orglett.8b02422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179452/
https://www.ncbi.nlm.nih.gov/pubmed/30221526
http://dx.doi.org/10.1021/acs.orglett.8b02422

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